Waterborne Risperidone Decreases Stress Response in Zebrafish.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26473477.
- Also identified by DOI 10.1371/journal.pone.0140800 and PMC identifier 4608780.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.
Medical subject headings
- Anti-Anxiety Agents
- Hypothalamo-Hypophyseal System
- Pituitary-Adrenal System
- Risperidone
- Water Pollutants, Chemical
- Zebrafish