Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis.
Where this comes from
- Record sourced from PubMed, PMID 26492493.
- Also identified by DOI 10.1371/journal.pone.0140549 and PMC identifier 4619591.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.
Medical subject headings
- Genetic Association Studies
- Genetic Predisposition to Disease
- Hydroxymethyl and Formyl Transferases
- Osteoporosis
- Polymorphism, Single Nucleotide