Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1-Infected Men.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 26494772.
- Also identified by DOI 10.1093/infdis/jiv501 and PMC identifier 4747622.
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Abstract
The aging of the human immunodeficiency virus type 1 (HIV-1)-infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1-infected men aged ≤ 35 years or ≥ 50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1-infected adults were also more frequently in the upper quartile of soluble CD14 expression.
Medical subject headings
- Aging
- Anti-HIV Agents
- Bacterial Translocation
- Chemokine CCL2
- HIV Infections
- HIV-1