Treatment for hypoactive sexual desire.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26496594.
- Also identified by DOI 10.1016/j.cell.2015.10.015.
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Abstract
Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors. This gradually disinhibits the turnover of other monoamines like dopamine and noradrenaline that are critical for sexual desire.
Medical subject headings
- Benzimidazoles
- Serotonin Antagonists
- Sexual Dysfunctions, Psychological