Vitamin D Status among Young Children Aged 1-3 Years: A Cross-Sectional Study in Wuxi, China.

Abstract

BACKGROUND: The increasingly recognized importance of vitamin D has been discussed and vitamin D status among young children has attracted widespread attention in recent years. However, study on vitamin D status in young children aged 1-3 y is limited in China. OBJECTIVE: To evaluate the nutritional vitamin D status of young children aged 1-3 y in Wuxi, southeastern China. METHODS: A large cohort of 5,571 young children aged 1-3 y were recruited in this study who visited the child health clinics at the Wuxi Maternity and Child Health Hospital (latitude 31.57°N) during January 2014 to January 2015. Wuxi was located in southeastern China at a latitude of 31.57°N. Finger-stick blood sampling was conducted in all the subjects and serum 25-Hydroxyvitamin D (25(OH)D) levels were measured to evaluate their vitamin D status. RESULTS: In this study, serum 25(OH)D levels of young children at the age of 1-3 years ranged from 20.6-132.9 nmol/L (Median: 71.5 nmol/L). 16.1% of the population had vitamin D deficiency (<50 nmol/L), while 38.8% of the subjects had a sufficient (50-74.9 nmol/L) vitamin D level. An optimal vitamin D status (≥75 nmol/L) was found in 45.1% of the young children. The prevalence of vitamin D deficiency was higher in autumn (19.5%) than in summer (12.1%). There was no significant difference in vitamin D status between genders. The binary logistic regression analysis revealed that child age was strongly associated with vitamin D deficiency (adjusted OR: 1.173; 95%CI: 1.053-1.308; P = 0.004). CONCLUSIONS: The prevalence of vitamin D deficiency was 16.1% among young children aged 1-3 y in Wuxi. Season and child age were associated with their vitamin D status. It is implied that young children should receive adequate amounts of vitamin D supplementation and spend more time outdoors to prolong the sunlight exposure when they grow older.