Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26509451.
- Also identified by DOI 10.1002/adma.201503676.
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Abstract
The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self-assembling, cell-targeted protein nanoparticles, including biodistribution upon in vivo administration.
Medical subject headings
- Nanotechnology
- Protein Engineering
- Proteins