Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 26510845.
- Also identified by DOI 10.1007/s00198-015-3380-y.
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Abstract
Osteoporosis treatments are usually given for a limited period of time in order to balance benefits and risks. We report three cases of postmenopausal women without any previous fragility fracture who presented severe spontaneous vertebral fractures after denosumab discontinuation. We think that the occurrence of these fractures could be explained by the severe rebound effect observed after denosumab discontinuation and that a consensus regarding the end of treatment with denosumab has to be defined.
Medical subject headings
- Bone Density Conservation Agents
- Denosumab
- Fractures, Spontaneous
- Osteoporotic Fractures
- Spinal Fractures