SeqSIMLA2_exact: simulate multiple disease sites in large pedigrees with given disease status for diseases with low prevalence.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 26515824.
- Also identified by DOI 10.1093/bioinformatics/btv626.
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Abstract
It is difficult for current simulation tools to simulate sequence data in a pre-specified pedigree structure and pre-specified affection status. Previously, we developed a flexible tool, SeqSIMLA2, for simulating sequence data in either unrelated case-control or family samples with different disease and quantitative trait models. Here we extended the tool to efficiently simulate sequences with multiple disease sites in large pedigrees with a given disease status for each pedigree member, assuming that the disease prevalence is low. SeqSIMLA2_exact is implemented with C++ and is available at http://seqsimla.sourceforge.net.
Medical subject headings
- Computer Simulation
- Disease
- Genetic Association Studies
- Genetics, Population
- Quantitative Trait, Heritable
- Software