Not Just a Drop in the Bucket-Inversion of Oxymetazoline Nasal Decongestant Container Increases Potential for Severe Pediatric Poisoning.
biomechanical · Level V
Where this comes from
- Record sourced from PubMed, PMID 26522979.
- Also identified by DOI 10.1016/j.jpeds.2015.09.067.
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Abstract
Oxymetazoline is an over-the-counter nasal decongestant with potent alpha agonist properties. In overdoses as small as 1-2 mL, toxicity can be seen including bradycardia and respiratory depression. We demonstrated that inverting the container increased the volume delivered 20- to 30-fold compared with holding it upright in an in vitro model.
Medical subject headings
- Administration, Intranasal
- Nasal Decongestants
- Oxymetazoline