Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26530232.
- Also identified by DOI 10.1039/c5lc01010a.
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Abstract
A silicon-based microarray system was constructed to discover the affinity peptides and to distinguish the specific peptides from a high throughput library. Using a color-encoding strategy, in situ peptide distinguishing between HER1 ligands and HER2 ligands was achieved. Novel affinity peptide sequences H1P (HER1 ligand) and H2P (HER2 ligand) were determined with nmol affinity.
Medical subject headings
- ErbB Receptors
- Peptide Library
- Peptides
- Protein Array Analysis
- Erb-b2 Receptor Tyrosine Kinases