Metabolic Mechanisms of Drug Resistance in Leukemia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26536486.
- Also identified by DOI 10.1016/j.cmet.2015.10.005.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Tumor cells frequently undergo metabolic reprogramming, but it is unknown how these metabolic changes relate to drug resistance. A recent article now demonstrates that PI3K/AKT signaling causes a metabolic switch from glutaminolysis to aerobic glycolysis in Notch-dependent T cell acute lymphoblastic leukemia (T-ALL).
Medical subject headings
- Drug Resistance, Neoplasm
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
- Receptors, Notch