Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26540021.
- Also identified by DOI 10.1002/adma.201502902 and PMC identifier 4825176.
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Abstract
Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.
Medical subject headings
- Glucose
- Hydrogels
- Mechanical Phenomena
- Polyethylene Glycols