A pathway to HIV-1 neutralization breadth.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 26540383.
- Also identified by DOI 10.1038/nm.3989 and PMC identifier 4769374.
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Abstract
Neutralization breadth is thought to be an important feature of an effective vaccine against HIV-1. A study in one individual has now identified the specific viral variant that engaged the necessary antibody precursor, as well as the viral immunotypes that drove neutralization breadth, improving understanding of how to mimic this process with a vaccine.
Medical subject headings
- AIDS Vaccines
- Antibodies, Neutralizing
- B-Lymphocytes
- HIV Antibodies
- HIV-1