A TGF-β pathway associated with cancer cachexia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26540384.
- Also identified by DOI 10.1038/nm.3988 and PMC identifier 4896299.
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Abstract
Cancer cachexia leads to involuntary weight loss resulting from the atrophy of skeletal muscle and adipose tissues. Now, in metastatic mouse models of cancer, investigators reveal a cross talk pathway between bone and muscle that provides a new understanding of wasting in advanced cancers.
Medical subject headings
- Bone Neoplasms
- Cachexia
- Muscle, Skeletal
- Neoplasms
- Transforming Growth Factor beta