Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 26541691.
- Also identified by DOI 10.1192/bjp.bp.114.152140.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis.
Medical subject headings
- Hippocampus
- Psychotic Disorders
- Sp1 Transcription Factor
- Sp4 Transcription Factor