AMPK Keeps Tumor Cells from Starving to Death.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26544110.
- Also identified by DOI 10.1016/j.stem.2015.10.007.
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Abstract
In this issue of Cell Stem Cell, Saito et al. (2015) examine how leukemia-initiating cells react to metabolic stress imposed by different tissue environments. They find that inhibition of the metabolic stress sensor AMP-activated protein kinase (AMPK) led to deranged glucose metabolism and redox homeostasis, resulting in reduced leukemic progression that was further attenuated by dietary restriction.
Medical subject headings
- AMP-Activated Protein Kinases
- Homeostasis