The Hedgehog Hold on Homeostasis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26544111.
- Also identified by DOI 10.1016/j.stem.2015.10.010.
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Abstract
The adult lung is largely quiescent, with airway epithelia turning over slowly. Peng et al. (2015) describe a key role for the Hedgehog pathway in actively maintaining this quiescence, a surprising turn of events given the pathway's established mitogenic role, and they show that Hedgehog pathway attenuation is required for proliferative regeneration.
Medical subject headings
- Hedgehog Proteins
- Lung
- Lung Injury
- Regeneration
- Wound Healing