Aire Gets Company for Immune Tolerance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26544932.
- Also identified by DOI 10.1016/j.cell.2015.10.057.
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Abstract
A specialized subset of epithelial cells in the thymus "promiscuously" transcribes thousands of peripheral genes to ensure that developing T cells can test their antigen receptors for dangerous autoreactivity. New findings by Takaba et al. indicate that the transcription factor Fezf2 acts independently of Aire in thymic epithelial cells to generate "genetic noise" for immunological tolerance.
Medical subject headings
- DNA-Binding Proteins
- Immune Tolerance
- Nerve Tissue Proteins
- Thymus Gland