NIR-Laser-Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26551334.
- Also identified by DOI 10.1002/adma.201502669.
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Abstract
In vivo MEO2 MA@MEO2 MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 °C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 °C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately.
Medical subject headings
- Antineoplastic Agents
- Carcinoma, Hepatocellular
- Hyperthermia, Induced
- Liver Neoplasms
- Low-Level Light Therapy
- Nanocapsules