Independent Control of Topography for 3D Patterning of the ECM Microenvironment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26551393.
- Also identified by DOI 10.1002/adma.201503950 and PMC identifier 4738476.
- Licence recorded as CC BY-NC-ND.
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Abstract
Biomimetic extracellular matrix (ECM) topographies driven by the magnetic-field-directed self-assembly of ECM protein-coated magnetic beads are fabricated. This novel bottom-up method allows us to program isotropic, anisotropic, and diverse hybrid ECM patterns without changing other physicochemical properties of the scaffold material. It is demonstrated that this 3D anisotropic matrix is able to guide the dendritic protrusion of cells.
Medical subject headings
- Biocompatible Materials
- Cellular Microenvironment
- Extracellular Matrix
- Tissue Scaffolds