Association Between Trabecular Meshwork Anteroposterior Length and Anterior Chamber Angle Width.

Abstract

To investigate the association between trabecular meshwork anteroposterior length and anterior chamber angle width in nonglaucomatous subjects. Prospective, cross-sectional study. Time-domain and spectral-domain anterior segment optical coherence tomography images for 561 eyes from 366 nonglaucomatous subjects were analyzed to determine trabecular meshwork anteroposterior length and 3 anterior chamber angle width parameters measured at different distances from the scleral spur: angle opening distance at 250 μm (AOD250), 500 μm (AOD500), and 750 μm (AOD750) from the scleral spur; trabecular-iris space area at 500 μm (TISA500) and 750 μm (TISA750) from the scleral spur; angle recess area at 750 μm (ARA750) from the scleral spur. Univariable and multivariable linear mixed-effect regression models, the latter adjusting for age, sex, ethnicity, axial length, and the use of both eyes in the same subject, were used to evaluate the association between trabecular meshwork anteroposterior length and anterior chamber angle width parameters. Mean trabecular meshwork anteroposterior length was 824.86 ± 181.77 μm. Univariate regression analyses showed a significant positive association between trabecular meshwork anteroposterior length and all anterior chamber angle width parameters: AOD250 (P < .001; β = 335.13), AOD500 (P < .001; β = 271.84), AOD750 (P < .001; β = 202.56), TISA500 (P < .001; β = 780.78), TISA750 (P < .001; β = 449.17), ARA750 (P < .001; β = 381.39). Multivariate regression analyses showed a significant positive association between trabecular meshwork anteroposterior length and all anterior chamber angle width parameters: AOD250 (P = .005; β = 294.02), AOD500 (P = .036; β = 172.94), AOD750 (P = .049; β = 125.58), TISA500 (P = .004; β = 611.51), TISA750 (P = .011; β = 333.96), ARA750 (P < .0001; β = 309.12). Wider anterior chamber angle is associated with greater trabecular meshwork anteroposterior length.