The Path to Cancer --Three Strikes and You're Out.
Where this comes from
- Record sourced from PubMed, PMID 26559569.
- Also identified by DOI 10.1056/NEJMp1508811.
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Abstract
Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.
Medical subject headings
- Cell Transformation, Neoplastic
- Mutation
- Neoplasms