Remote ischemic preconditioning enhances fracture healing.
basic_science · Level V
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- Record sourced from PubMed, PMID 26566314.
- Also identified by DOI 10.1016/j.jor.2015.05.020 and PMC identifier 4602003.
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Abstract
We hypothesized that RIP accelerates fracture healing. Rats (n = 48) were used for the technique of ischemic preconditioning involved applying 35 min of intermittent pneumatic tourniquet for 7 cycles of 5 min each to the fractured hind limb. We observed greater callus maturity in RIP group at first week after fracture when compared to controls (p < 0,0001). The serum MDA levels demonstrated statistically lower values at the RIP group at the first week after fracture; however, there were not significant differences at 3rd and 5th weeks (p = 0.0001, p = 0.725, p = 0.271, respectively). Greater callus maturity was obtained in RIP group.