A Near-Infrared Laser-Activated "Nanobomb" for Breaking the Barriers to MicroRNA Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26567892.
- Also identified by DOI 10.1002/adma.201504263.
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Abstract
A near-infrared laser-activated "nanobomb" is synthesized using lipid and multiple polymers to break the extra-cellular and intracellular barriers to cytosolic delivery of microRNAs. The nanobomb can be used to effectively destroy tumors and cancer stem-like cells in vitro and in vivo with minimal side effects.
Medical subject headings
- Genetic Therapy
- Laser Therapy
- MicroRNAs
- Nanoparticles