Global copy number profiling of cancer genomes.
basic_science · Level V
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- Record sourced from PubMed, PMID 26576652.
- Also identified by DOI 10.1093/bioinformatics/btv676 and PMC identifier 4907391.
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Abstract
In this article, we introduce a robust and efficient strategy for deriving global and allele-specific copy number alternations (CNA) from cancer whole exome sequencing data based on Log R ratios and B-allele frequencies. Applying the approach to the analysis of over 200 skin cancer samples, we demonstrate its utility for discovering distinct CNA events and for deriving ancillary information such as tumor purity. https://github.com/xfwang/CLOSE CONTACT: xuefeng.wang@stonybrook.edu or michael.krauthammer@yale.edu Supplementary data are available at Bioinformatics online.
Medical subject headings
- DNA Copy Number Variations