Replenishment of the podocyte compartment by parietal epithelial cells.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 26579676.
- Also identified by DOI 10.1038/ki.2015.256.
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Abstract
While progressive podocytopenia is a characteristic feature of chronic glomerular disease, the visceral epithelial niche can be replenished from the parietal epithelium. Two new reports demonstrate this process in genetically engineered mice, using fate mapping, and in human renal biopsies manifesting segmental glomerulosclerosis in diverse settings, using cellular and extracellular matrix markers.
Medical subject headings
- Glomerulosclerosis, Focal Segmental
- Podocytes