Vitamin D: can you have too much of a good thing in chronic kidney disease?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26579677.
- Also identified by DOI 10.1038/ki.2015.257.
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Abstract
Recommendation of vitamin D supplements is common although there is little information regarding the definition of the upper limit of safety. Kusunoki et al. now publish interesting data of a novel mechanism by which excess 25-hydroxyvitamin D exerts adverse effects on the kidney, using unilateral ureteral obstruction in the mouse as a model of kidney disease. Their report provides a new mechanism to be assessed as a surrogate measure of vitamin D toxicity that may be clinically relevant.
Medical subject headings
- Renal Insufficiency, Chronic
- Vitamin D