What is myeloperoxidase doing in ANCA-associated glomerulonephritis?
Level V
Where this comes from
- Record sourced from PubMed, PMID 26579678.
- Also identified by DOI 10.1038/ki.2015.259.
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Abstract
O'Sullivan et al. describe glomerular localization of myeloperoxidase (MPO) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and correlate the amount of deposition with severity of injury. MPO is the antigen against which anti-MPO ANCAs are directed, the antigen to which pathogenic T cells that can induce antibody-independent AAV are directed, and MPO can induce glomerular injury directly by interacting with H2O2 and a halide to halogenate glomerular structures. All three of these roles are likely involved in human disease.
Medical subject headings
- Antibodies, Antineutrophil Cytoplasmic
- Peroxidase