Prolonged and Severe Gestational Thyrotoxicosis Due to Enhanced hCG Sensitivity of a Mutant Thyrotropin Receptor.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 26580241.
- Also identified by DOI 10.1210/jc.2015-3670.
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Abstract
Gestational thyrotoxicosis, whether associated with hyperemesis gravidarum or not, is thought to be due to excessive human chorionic gonadotropin (hCG) secretion. We report here the second case of gestational thyrotoxicosis associated with hyperemesis gravidarum due to a mutation of the TSH receptor, providing thyroid hypersensitivity to hCG. Severe and lasting gestational thyrotoxicosis with normal hCG concentration should lead to sequencing of the TSH receptor gene.
Medical subject headings
- Chorionic Gonadotropin
- Pregnancy Complications
- Receptors, Thyrotropin
- Thyrotoxicosis