Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons.
Where this comes from
- Record sourced from PubMed, PMID 26587987.
- Also identified by DOI 10.1371/journal.pone.0143432 and PMC identifier 4654514.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.
Medical subject headings
- Bipolar Disorder
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide