Potent Antibody Protection against an Emerging Alphavirus Threat.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26590413.
- Also identified by DOI 10.1016/j.cell.2015.11.006.
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Abstract
Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.
Medical subject headings
- Alphavirus
- Alphavirus Infections
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antibodies, Viral
- Epitopes
- Viral Envelope Proteins