Establishment and Dysfunction of the Blood-Brain Barrier.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26590417.
- Also identified by DOI 10.1016/j.cell.2015.10.067 and PMC identifier 4655822.
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Abstract
Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.
Medical subject headings
- Blood-Brain Barrier
- Nervous System Diseases