An Apoferritin-based Drug Delivery System for the Tyrosine Kinase Inhibitor Gefitinib.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26592186.
- Also identified by DOI 10.1002/adhm.201500389.
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Abstract
Anticancer drug Gefitinib encapsulated within human heavy chain apoferritin by diffusion allows pH-controlled sustained release of cargo. The combination of increased cellular uptake, and potent and enhanced antitumor activity against the HER2 overexpressing SKBR3 cell line compared to Gefitinib alone, makes it a promising carrier for delivery of drugs to tumor sites.
Medical subject headings
- Apoferritins
- Drug Delivery Systems
- Protein Kinase Inhibitors
- Quinazolines