Why clinical translation cannot succeed without failure.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26599839.
- Also identified by DOI 10.7554/eLife.12844 and PMC identifier 4657068.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The high rates of attrition that occur in drug development are widely regarded as problematic, but the failure of well-designed studies benefits both researchers and healthcare systems by, for example, generating evidence about disease theories and demonstrating the limits of proven drugs. A wider recognition of these benefits will help the biomedical research enterprise to take full advantage of all the information generated during the drug development process.
Medical subject headings
- Clinical Trials as Topic
- Drug Discovery
- Drug Evaluation, Preclinical
- Translational Research, Biomedical