Is in vivo amyloid distribution asymmetric in primary progressive aphasia?
case_control · Level III
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- Record sourced from PubMed, PMID 26600088.
- Also identified by DOI 10.1002/ana.24566 and PMC identifier 4789129.
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Abstract
We aimed to determine whether (18) F-florbetapir amyloid positron emission tomography imaging shows a clinically concordant, left-hemisphere-dominant pattern of deposition in primary progressive aphasia (PPA). Elevated cortical amyloid (Aβ(+) ) was found in 19 of 32 PPA patients. Hemispheric laterality of amyloid burden was compared between Aβ(+) PPA and an Aβ(+) amnestic dementia groups (n = 22). The parietal region showed significantly greater left lateralized amyloid uptake in the PPA group than the amnestic group (p < 0.007), consistent with the left lateralized pattern of neurodegeneration in PPA. These results suggest that the cortical distribution of amyloid may have a greater clinical concordance than previously reported.
Medical subject headings
- Amyloid beta-Peptides
- Aphasia, Primary Progressive
- Cerebral Cortex
- Dominance, Cerebral
- Molecular Imaging