VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires.
Where this comes from
- Record sourced from PubMed, PMID 26606115.
- Also identified by DOI 10.1371/journal.pcbi.1004503 and PMC identifier 4659587.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Despite the growing number of immune repertoire sequencing studies, the field still lacks software for analysis and comprehension of this high-dimensional data. Here we report VDJtools, a complementary software suite that solves a wide range of T cell receptor (TCR) repertoires post-analysis tasks, provides a detailed tabular output and publication-ready graphics, and is built on top of a flexible API. Using TCR datasets for a large cohort of unrelated healthy donors, twins, and multiple sclerosis patients we demonstrate that VDJtools greatly facilitates the analysis and leads to sound biological conclusions. VDJtools software and documentation are available at https://github.com/mikessh/vdjtools.
Medical subject headings
- Computational Biology
- Receptors, Antigen, T-Cell
- Sequence Analysis, DNA
- Software