LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26610188.
- Also identified by DOI 10.1002/adhm.201500608 and PMC identifier 4776323.
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Abstract
In vitro biomimetic modeling of physio-logical structures bridges the gap between 2D in vitro culture and animal models. Lumens (tubular structures) are ubiquitous in vivo, being present in blood vessels, mammary ducts, and the lymphatic system. A method 'LumeNEXT' is presented here that allows the fabrication of 3D embedded lumens where size, structure, distance, and configuration can be controlled using standard poly-dimethylsiloxane micromolding methods.
Medical subject headings
- Extracellular Matrix
- Gels
- Tissue Engineering