NIR-Remote Selected Activation Gene Expression in Living Cells by Upconverting Microrods.
basic_science · Level V
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- Record sourced from PubMed, PMID 26619378.
- Also identified by DOI 10.1002/adma.201503961.
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Abstract
An NIR-controlled gene expression system based on upconverting rods (UCRs) is demonstrated. The UCRs can harvest the "biocompatible" NIR light and convert it into local UV light, resulting in cleavage of the photosensitive molecule (4-(hydroxymethyl)-3-nitrobenzoic acid, ONA) and on-demand release of gene carriers, thus realizing target gene expression at high spatial and temporal resolutions.
Medical subject headings
- Infrared Rays
- Nanoparticles