In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26627192.
- Also identified by DOI 10.1002/adhm.201500826.
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Abstract
Cationic nanohydrogel particles loaded with anti-Col1α1 siRNA suppress collagen synthesis and deposition in fibrotic mice: Systemically administered 40 nm sized nanogel particles accumulate in collagen-expressing cells in the liver. Their siRNA payload induces a sequence specific in vivo gene knockdown affording an efficient antifibrotic effect in mice with liver fibrosis.
Medical subject headings
- Gene Silencing
- Hydrogels
- Liver Cirrhosis
- Polyethylene Glycols
- Polyethyleneimine
- RNA, Small Interfering