SCFAs Take a Toll En Route to Metabolic Syndrome.
Where this comes from
- Record sourced from PubMed, PMID 26636491.
- Also identified by DOI 10.1016/j.cmet.2015.11.006.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Gut dysbiosis is associated with development of metabolic syndrome in Tlr5(-/-) mice, but the underlying mechanism remains unclear. In this issue, Singh et al. (2015) report that augmented SCFA levels play a deleterious role in metabolic syndrome by promoting conversion of SFA to oleate in Tlr5(-/-) mice via increased liver SCD1expression.
Medical subject headings
- Liver
- Metabolic Syndrome