Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26636492.
- Also identified by DOI 10.1016/j.cmet.2015.11.008.
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Abstract
The role of reactive oxygen species (ROS) and antioxidants in cancer is controversial because of their context-dependent ability to promote or suppress tumorigenesis. Piskounova et al. (2015) now show that ROS limit distant metastasis: only cells with increased antioxidant capacity are able to succeed in their purpose to metastasize.
Medical subject headings
- Melanoma
- Neoplasm Metastasis
- Oxidative Stress