Leukemogenic Activity of Cohesin Rings True.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26637939.
- Also identified by DOI 10.1016/j.stem.2015.11.008.
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Abstract
Cohesin complex components are frequently mutated in human myeloid cancers. Three new studies now show that cohesin mutations disrupt the differentiation of normal hematopoietic stem and progenitor cells and enhance self-renewal, shedding light on how these alterations may contribute to leukemic transformation.
Medical subject headings
- Cell Differentiation
- Hematopoietic Stem Cells