A Metabolic Switch for Th17 Pathogenicity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26638065.
- Also identified by DOI 10.1016/j.cell.2015.11.033.
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Abstract
T helper 17 (Th17) cells are critical for host defense but can also drive autoimmunity. This divergent behavior is explored by Gaublomme et al. and Wang et al., who identify inflammation-associated genes by measuring gene expression in nearly 1,000 individual Th17 cells and show that CD5L affects the expression of pro-inflammatory genes by altering lipid synthesis.
Medical subject headings
- Encephalomyelitis, Autoimmune, Experimental
- Sequence Analysis, RNA
- Single-Cell Analysis
- Th17 Cells