Interleukin-18: The Bouncer at the Mucosal Bar.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26638066.
- Also identified by DOI 10.1016/j.cell.2015.11.041.
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Abstract
The fidelity of the intestinal barrier is critical to maintaining a healthy relationship between the immune system and the microbiota. Levy et al. and Nowarski et al. reveal how microbiota-derived metabolites modulate the activation of the inflammasome to influence the expression of the cytokine IL-18, intestinal barrier function, and intestinal inflammation.
Medical subject headings
- Colitis, Ulcerative
- Colon
- Inflammasomes
- Interleukin-18
- Microbiota
- Receptors, Cell Surface
- Signal Transduction