Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26640034.
- Also identified by DOI 10.1002/adma.201504797.
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Abstract
The site-specific conjugation of polymers to multiple engineered cysteine residues of a prolyl endopeptidase leads to its stabilization in the gastrointestinal tract of rats, without compromising the activity relative to the native enzyme. The importance of polymer attachment sites is investigated, as well as the significance of polymer structure.
Medical subject headings
- Endopeptidases
- Gastrointestinal Tract
- Polyethylene Glycols