Development of an Amino Acid-Functionalized Fluorescent Nanocarrier to Deliver a Toxin to Kill Insect Pests.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26640174.
- Also identified by DOI 10.1002/adma.201504993.
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Abstract
Large-scale cultivation of Bacillus thuringiensis Berliner (Bt) crops has led to the rapid development of drug resistance. Herein, a fluorescent star poly(amino acid) is synthesized with l-isoleucine functionalization for the efficient delivery of either positively or negatively charged exogenous proteins into live cells. Poly(amino acid)s (P1)/Cry1Ab complexes greatly increase the cytotoxicity of the Bt toxin, Cry1Ab, and efficiently kill Bt-resistant pests.
Medical subject headings
- Amino Acids
- Bacterial Toxins
- Drosophila melanogaster
- Drug Carriers
- Fluorescent Dyes
- Nanostructures
- Pest Control, Biological