Identification and characterization of latency-associated peptide-expressing γδ T cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26644347.
- Also identified by DOI 10.1038/ncomms9726 and PMC identifier 4686827.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
γδ T cells are a subset of lymphocytes specialized in protecting the host against pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-β1. Thymic CD27+IFN-γ+CCR9+α4β7+TCRγδ+ cells migrate to the periphery, particularly to Peyer's patches and small intestine lamina propria, where they upregulate LAP, downregulate IFN-γ via ATF-3 expression and acquire a regulatory phenotype. TCRγδ+LAP+ cells express antigen presentation molecules and function as antigen presenting cells that induce CD4+Foxp3+ regulatory T cells, although TCRγδ+LAP+ cells do not themselves express Foxp3. Identification of TCRγδ+LAP+ regulatory cells provides an avenue for understanding immune regulation and biologic processes linked to intestinal function and disease.
Medical subject headings
- Colitis
- Cytokines
- Intestinal Mucosa
- Peyer's Patches
- Receptors, Antigen, T-Cell, gamma-delta
- T-Lymphocyte Subsets
- T-Lymphocytes, Regulatory
- Transforming Growth Factor beta1