Isoflurane Post-Treatment Improves Outcome after an Embolic Stroke in Rabbits.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26645542.
- Also identified by DOI 10.1371/journal.pone.0143931 and PMC identifier 4672898.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Application of commonly used volatile anesthetics after brain ischemia onset (post-treatment) provides neuroprotection in rodents. To further test its translational potential, this study was designed to determine whether isoflurane post-treatment induced neuroprotection in rabbits after embolic stroke. White male New Zealand rabbits received intra-carotid injection of clots when they were awake. Some rabbits were exposed to 2.5% isoflurane for 1 h at 5 min after the injection. Isoflurane post-treatment increased the tolerance of rabbits to the amount of clots. Isoflurane post-treatment also reduced brain infarct volumes and plasma S100B 3 days after the injection of 5 mg clots and improved neurological deficit scores after the stroke. Isoflurane post-treatment improves neurological outcome in rabbits after embolic stroke.
Medical subject headings
- Anesthetics, Inhalation
- Cerebral Infarction
- Embolism
- Isoflurane