Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFNγ Autoantibodies.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 26646678.
- Also identified by DOI 10.1093/cid/civ995 and PMC identifier 4772847.
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Abstract
Interferon-gamma (IFNγ) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNγ-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNγ contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.
Medical subject headings
- Anti-Bacterial Agents
- Antibodies, Neutralizing
- Autoantibodies
- Interferon-gamma
- Tuberculosis, Miliary