Driving change: kidney proximal tubule CSF-1 polarizes macrophages.
basic_science · Level V
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- Record sourced from PubMed, PMID 26649657.
- Also identified by DOI 10.1038/ki.2015.324 and PMC identifier 4976441.
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Abstract
Macrophage colony-stimulating factor (CSF-1 or M-CSF) is important for kidney repair after acute kidney injury (AKI). CSF-1 is upregulated in tubule epithelial cells in response to kidney injury stimuli and binds to its sole receptor, CSF1R, in an autocrine and paracrine manner. Wang and colleagues used a genetic approach to constitutively delete Csf1 in proximal tubules to establish that proximal tubule production of CSF-1 is important for polarizing and skewing macrophages toward an M2 phenotype, and for recovery from AKI.